Gamma-glutamylcyclotransferase
Template:Short description Template:Infobox enzyme In enzymology, a gamma-glutamylcyclotransferase (EC 2.3.2.4) is an enzyme that catalyzes the chemical reaction
- (5-L-glutamyl)-L-amino acid 5-oxoproline + L-amino acid
Hence, this enzyme has one substrate, (5-L-glutamyl)-L-amino acid, and two products, 5-oxoproline and L-amino acid.
This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing). Other names in common use include gamma-glutamyl-amino acid cyclotransferase, gamma-L-glutamylcyclotransferase, and L-glutamic cyclase. This enzyme participates in glutathione metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2PN7 and 2RBH.
References
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