Glycogen synthase kinase-3 beta

Template:Short description Template:Cs1 config Template:Infobox gene Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the Gsk3b gene. Abnormal regulation and expression of GSK-3 beta is associated with an increased susceptibility towards bipolar disorder.

Function

Glycogen synthase kinase-3 (GSK-3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and an inactivating agent of glycogen synthase. Two isoforms, alpha (GSK3A) and beta, show a high degree of amino acid homology. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation. It might be a new therapeutic target for ischemic stroke.

Disease relevance

Homozygous disruption of the Gsk3b locus in mice results in embryonic lethality during mid-gestation. This lethality phenotype could be rescued by inhibition of tumor necrosis factor.

Two SNPs at this gene, rs334558 (-50T/C) and rs3755557 (-1727A/T), are associated with efficacy of lithium treatment in bipolar disorder.

Signaling pathways

Pharmacological inhibition of ERK1/2 restores GSK-3 beta activity and protein synthesis levels in a model of tuberous sclerosis.

Interactions

GSK3B has been shown to interact with:

• KIAA1211L
• ATP2A2

• AKAP11,
• AXIN1,
• AXIN2,
• AR,
• CTNNB1,
• DNM1L,
• MACF1
• MUC1,
• SMAD3
• NOTCH1,
• NOTCH2,
• P53,
• PRKAR2A,
• SGK3, and
• TSC2.

File:Signal transduction v1.png

Overview of signal transduction pathways involved in apoptosis.

See also

• Glycogen synthase kinase 3

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Glycogen synthase kinase-3 beta (GSK3B)