GPR25
Template:Short description Template:Cs1 config Template:Infobox gene Probable G-protein coupled receptor 25 is a protein that in humans is encoded by the GPR25 gene.[1][2].
Structure
It is a member of the G protein-coupled receptor (GPCR) family and it's well conserved in vertebrate evolution containing a canonical DRYLAVV motif in the third transmembrane sequence. It has a conserved negatively charged N-terminal extracellular peptide comprising a DY candidate sulfation site that is characteristic of many leukocyte chemoattractant receptors for positively charged polypeptides of the chemokine family.[3]
Tissue distribution
GPR25 expression is largely restricted to lymphocytes and natural killer (NK) cells.[3]
Function
It has been identified as the receptor for the chemokine-like protein CXCL17.[3]
References
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Further reading
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