GPR143

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Script error: No such module "Infobox".Template:Template other G-protein coupled receptor 143, also known as Ocular albinism type 1 (OA1) in humans, is a conserved integral membrane protein with seven transmembrane domains and similarities with G protein-coupled receptors (GPCRs) that is expressed in the eye and epidermal melanocytes.[1][2][3] This protein encoded by the GPR143 gene,[4][5] whose variants can lead to Ocular albinism type 1.[6]

The GPR143 gene is regulated by the Microphthalmia-associated transcription factor.[7][8]

L-DOPA is an endogenous ligand for OA1.[9]

Interactions

GPR143 has been shown to interact with GNAI1.[5]

References

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Further reading

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External links

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