Fructose 6-phosphate
Fructose 6-phosphate (sometimes called the Neuberg ester) is a derivative of fructose, which has been phosphorylated at the 6-hydroxy group. It is one of several possible fructosephosphates. The β-D-form of this compound is very common in cells.[1][2] The great majority of glucose is converted to fructose 6-phosphate upon entering a cell. Fructose is predominantly converted to fructose 1-phosphate by fructokinase following cellular import.
History
The name Neuberg ester comes from the German biochemist Carl Neuberg. In 1918, he found that the compound (later identified as fructose 6-phosphate) was produced by mild acid hydrolysis of fructose 2,6-bisphosphate.[3]
In glycolysis
Fructose 6-phosphate lies within the glycolysis metabolic pathway and is produced by isomerisation of glucose 6-phosphate. It is in turn further phosphorylated to fructose-1,6-bisphosphate.
| α-DScript error: No such module "Check for unknown parameters".-glucose 6-phosphate | Phosphoglucose isomerase | α-DScript error: No such module "Check for unknown parameters".-fructose 6-phosphate | Phosphofructokinase-1 | α-DScript error: No such module "Check for unknown parameters".-fructose 1,6-bisphosphate | ||
| File:Alpha-D-glucose-6-phosphate wpmp.png | File:Beta-D-fructose-6-phosphate wpmp.png | File:Beta-D-fructose-1,6-bisphosphate wpmp.png | ||||
| ATP | ADP | |||||
| File:Biochem reaction arrow reversible NNNN horiz med.svg | File:Biochem reaction arrow reversible YYYY horiz med.svg | |||||
| Pi | H2O | |||||
| Phosphoglucose isomerase | Fructose bisphosphatase | |||||
Compound C00668 at KEGG Pathway Database. Enzyme 5.3.1.9 at KEGG Pathway Database. Compound C05345 at KEGG Pathway Database. Enzyme 2.7.1.11 at KEGG Pathway Database. Enzyme 3.1.3.11 at KEGG Pathway Database. Reaction [1] at KEGG Pathway Database. Compound C05378 at KEGG Pathway Database.
Template:GlycolysisGluconeogenesis WP534
See also
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Template:Biochem reaction subunit Template:Biochem reaction subunit Template:Biochem reaction subunit Template:Biochem reaction subunit Template:Biochem reaction subunit Template:Biochem reaction subunit Template:Biochem reaction subunit Template:Biochem reaction subunit
References
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- ↑ Script error: No such module "citation/CS1".
- ↑ Nelson, D. L.; Cox, M. M. "Lehninger, Principles of Biochemistry" 3rd Ed. Worth Publishing: New York, 2000. Template:ISBN.
- ↑ Fruton, Joseph S. Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology. Yale University Press: New Haven, 1999. p 292
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