Fosfluconazole
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| _other_data={[2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-yl]oxy}phosphonic acid
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| _datapage = Fosfluconazole (data page) | _vaccine_target=_type_not_vaccine | _legal_all=Rx-only | _ATC_prefix_supplemental=none | _has_EMA_link = | CAS_number=194798-83-9 | PubChem=214356 | ChemSpiderID=185843 | ChEBI= | ChEMBL=1908301 | DrugBank= | KEGG= | _hasInChI_or_Key=yes | UNII=3JIJ299EWH | _hasJmol02 = |_hasMultipleCASnumbers = |_hasMultiplePubChemCIDs = |_hasMultipleChEBIs =
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Fosfluconazole (INN) is a water-soluble phosphate prodrug of fluconazole[1] — a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.[2]
The phosphate ester bond is hydrolyzed by the action of a phosphatase — an enzyme that removes a phosphate group from its substrate by hydrolyzing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (dephosphorylation).[3]
References
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