Fixed-dose procedure
Template:Short description The fixed-dose procedure (FDP), proposed in 1992 by the British Toxicology Society, is a method to assess a substance's acute oral toxicity.[1][2]
In comparison to the older LD50 test developed in 1927, this procedure produces similar results while using fewer animals and causing less pain and suffering.[3] As a result, in 1992 this test was proposed as an alternative to the LD50 test by the Organisation for Economic Co-operation and Development under OECD Test Guideline 420.[4] However, the U.S. Food and Drug Administration has begun to approve non-animal alternatives in response to research cruelty concerns and the lack of validity/sensitivity of animal tests as they relate to humans.[5][6]
See also
References
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Further reading
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