Farletuzumab
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Template:Short description Template:Drugbox Farletuzumab (MORAb-003) is a humanized monoclonal antibody[1] of IgG1/κ[2] which is being investigated for the treatment of ovarian cancer.[3][4]
This drug was developed by Morphotek, Inc.
It is targeted at folate receptor alpha (FRα) which is overexpressed in some cancers such as epithelial ovarian cancer (EOC) and non-small-cell lung carcinoma.[2]
Mechanism of action
Farletuzumab uses the following mechanisms of action:[2]
- Antibody-dependent cellular cytotoxicity
- Complement-dependent cytotoxicity
- Inhibition of interaction between FRα and Lyn kinase
- Induces cell death associated with autophagy
Adverse effects
Common adverse effects include hypersensitivity reactions, fever, chills, headache, fatigue, and diarrhea.[2]
References
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- ↑ Statement On A Nonproprietary Name Adopted By The Usan Council - Farletuzumab, American Medical Association.
- ↑ a b c d Script error: No such module "Citation/CS1".
- ↑ Clinical trial number NCT00738699 for "Phase II Efficacy and Safety Study of MORAb-003 in Platinum-Resistant or Refractory Relapsed Ovarian Cancer" at ClinicalTrials.gov
- ↑ Clinical trial number NCT00849667 for "Phase III Efficacy and Safety of MORAb-003 in Subjects With Platinum-sensitive Ovarian Cancer in First Relapse" at ClinicalTrials.gov
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