FRS2

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Template:Short description Template:Infobox gene Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.[1][2][3][4]

FRS2 is an 80 kDa membrane-anchored signal transducing adaptor protein (STAP) that links specific activated Receptor Tyrosine Kinases (RTKs) to multiple downstream signaling pathways, most notably the MAPK/ERK, PI3K/AKT/mTOR and PLCγ pathways.[5] It is overexpressed and amplified in several cancer types, including prostate cancer.[6][7]

Interactions

FRS2 has been shown to interact with:

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References

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Further reading

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