FAM114A2
Template:Short description Template:Infobox gene FAM114A2 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. The protein function is not well known. FAM114A2 is, however, highly conserved in mammals with homologs both in fungi and plants.
| Species | Accession # | Identity |
|---|---|---|
| macaca mulatta | XM_001102467 | 78.1% |
| Pan troglodytes | XM_518045 | 89.7% |
| bos taurus | NP_001033166 | 85.6% |
| Pongo abelii | XM_002816109 | 87.8% |
| Mus musculus | NM_026342.3 | 79% |
| Callithrix jacchus | XP_002744467 | 94.7% |
Protein
The FAM114A2 protein is 505 amino acids long[1] with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.[2] It is predicted to stay in the nucleus after translation [3] There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 [4] This protein is thought to include a P loop[5] that suggests a role in ATP- and/or GTP-binding [6]
Gene
The FAM114A2 gene is located on chromosome 5 (5q31-33).[7] This gene has 14 exons spanning through its sequence.[1] The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs.[1] It is expressed at high levels in most tissues of the human body.[7] It is also highly expressed in tissues in the human brain [8]
References
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- ↑ a b c Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI
- ↑ Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#Script error: No such module "Unsubst".!
- ↑ PSORT WWW Server
- ↑ STRING: http://string-db.org/newstring_cgi/show_network_section.pl.
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- ↑ a b FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody
- ↑ Allen Brain Atlas: http://human.brain-map.org/search?type=mi Script error: No such module "webarchive".
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External links
Further reading
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