Ethocybin
Template:Short description Template:Drugbox
Ethocybin (code name CEY-19), also known as 4-phosphoryloxy-N,N-diethyltryptamine (4-PO-DET), is a homologue of the mushroom alkaloid psilocybin, and a semi-synthetic psychedelic alkaloid of the tryptamine family.[1]
Pharmacology
Ethocybin may be dephosphorylated in vivo to 4-HO-DET (ethocin), analogously to how psilocybin is metabolized to psilocin.[2] This chemical reaction takes place under strongly acidic conditions or enzymatically by phosphatases in the body. 4-HO-DET acts as a partial agonist at the 5-HT2A serotonin receptor.[3][4]
History
Albert Hofmann was the first to produce ethocybin, soon after his discovery of psilocin and psilocybin.[5][6] It was first described by 1963.[5][6] The drug was known under the code name CEY-19.[6]
Legal status
United States
Ethocybin is not controlled in the United States, but possession or sale may be considered illegal under the Federal Analog Act.
Research
Ethocybin has been studied as a treatment for several disorders since the early 1960s, and numerous papers are devoted to this material.Script error: No such module "Unsubst". Its short-lived action was considered a virtue. A 2010 study found that ethocybin helped with bipolar affective disorder.Script error: No such module "Unsubst".
References
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External links
- 4-PO-DET (Ethocybin) - Isomer Design
- 4-HO-DET and 4-H2PO4-DET - TiHKAL - Isomer Design
- 4-HO-DET and 4-H2PO4-DET - TiHKAL - Erowid
- - CEY 19 - Trout's Notes
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