Enteroglucagon
Enteroglucagon is a peptide hormone derived from preproglucagon. It is a gastrointestinal hormone, secreted from mucosal cells primarily of the colon and terminal ileum.[1] It consists of 37 amino acids. Enteroglucagon is released when fats and glucose are present in the small intestine; which decrease the motility to allow sufficient time for these nutrients to be absorbed.
Discovery
In 1948, Sutherland and De Duve identified a gastrointestinal glucagon-like material in gastric mucosa,[2] the term "enteroglucagon" was used to describe this material that shared a similar immunoreactivity with glucagon.[3] A half-century later, Brubaker and Drucker[4] studied proglucagon gene expression, they discovered the function of enteroglucagon is related to the growth of intestinal epithelium.[5]
Function
Enteroglucagon is a proglucagon-derived peptide or enteroendocrine cells derived peptide in the small intestine. Preproglucagon undergoes post translational modification to release glucagon-like peptides (GLP-1 and GLP-2) and other molecules derived from L-cells of intestine. GLP-1 is derived from a class of intestinal hormones called incretin and the molecule exists in two forms GLP-1(7-37) and GLP-1(7-36) amide.[6] GLP-1 form of incretin starts circulating in response to a high blood glucose level. Incretin effect is a negative feedback loop between glucose and insulin level, it promotes insulin release from beta cells of pancreas islet and suppresses glucagon when the glucose level is high.[7] In vertebrate mammals, GLP-2 sequences are highly conversed in the intestine.[2] The molecule functions as a part of adaptive response, such that contributes intestinal growth, proliferation effect, intestinal dilation (increases the mucosal blood flow) and reduces the chance of apoptosis.[2]
Clinical significance
GLP-1 is effective at reducing blood glucose levels. GLP-1 analogs have a significant therapeutic effect and high efficacy on diabetes treatments and hypoglycemia prevention.[8] Proliferation effect and trophic effect on the small intestine, GLP-2 is used as a therapy to support patients with short-bowel syndrome and other underlying intestinal conditions.[9]
See also
References
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External links
- Overview at colostate.edu
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- Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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