EMD-386088
Template:Short description Template:Drugbox
EMD-386088 is an indole derivative which is used in scientific research. It acts as a potent 5-HT6 receptor partial agonist, with a Ki of 1 nM, a significantly higher affinity than older 5-HT6 agonists such as EMDT, although it possesses moderate affinity for the 5-HT3 receptor as well.[1] Subsequent research has determined that EMD-386088 is also a dopamine reuptake inhibitor and that this action is involved in the antidepressant-like effects of the drug in rodents.[2]
EMD-386088 can be further reacted with a butyrophenone sidechain.[3]
See also
References
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- ↑ Genus Possanza, Kurt Freter, & Sven Luttke, U.S. patent 3980658 (1976 to Boehringer Ingelheim GmbH).
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Template:Dopamine receptor modulators Template:Serotonin receptor modulators