E4F1
Template:Cs1 config Template:Short description Template:Infobox gene Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.[1][2][3]
Function
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.[3]
Interactions
E4F1 has been shown to interact with:
References
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Further reading
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.