E300

E300 or E-300 may refer to:

• Alexander Dennis Enviro300, a popular British bus built upon various chassis
• Brandner E-300, an Egyptian turbojet engine
• HB-E300 series, a Japanese hybrid diesel train type
• Olympus E-300, a digital camera manufactured by Olympus
• PowerPC e300, a family of microprocessor cores
• Ascorbic acid, a compound numbered E300 in the European food additive E number system
• Eurostar e300, a class of Eurostar passenger trains also known as British Rail Class 373 and TGV TMST
• Extra 300, an acrobatic monoplane