E2F1
Template:Short description Template:Cs1 config Script error: No such module "Unsubst".Template:Infobox gene Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.[1]
Function
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.[2]
Transcription
E2F1 promoter[PAX8] => E2F1[3]
Interactions
E2F1 has been shown to interact with:
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- ARID3A,[4]
- CUL1,[5]
- Cyclin A1,[6]
- Cyclin A2,[7]
- GTF2H1,[8]
- MDM4,[9]
- NCOA6,[10]
- NDN,[11][12]
- NPDC1,[13]
- PURA,[14]
- PHB,[15][16][17][18]
- RB1,[11][19][20][21][22][23][24]
- UDG,[25]
- RBL1,[19]
- SKP2,[5]
- SP1,[26][27][28]
- SP2,[26]
- SP3,[26]
- SP4,[26]
- TFDP1[4][24][29][30]
- TOPBP1,[31][32]
- TP53BP1,[22] and
- UBC.[33]
See also
References
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Further reading
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External links
Template:PDB Gallery Template:Transcription factors This article incorporates text from the United States National Library of Medicine, which is in the public domain.