Dynorphin A

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Dynorphin A is a dynorphin, an endogenous opioid peptide that activates the κ-opioid receptor.[1] Its amino acid sequence is Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys, a tridecapeptide.

Dynorphin A1–8 is a truncated form of dynorphin A with the amino acid sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile.[2][3] Dynorphin A1–8 is an agonist at the mu-, kappa-, and delta-opioid receptors;[3] it has the highest binding affinity for the kappa-opioid receptor.[3] Structures of dynorphin A bound to the κ-opioid receptor have been reported.[1][4]

References

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