Dixyrazine
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| Template:Longitem | C24H33N3O2S |
| Molar mass | 427.60272 g/mol |
| Template:Longitem | N05AB01 (WHO) |
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Dixyrazine, also known as dixypazin (oxalate), sold under the brand names Ansiolene, Esocalm, Esucos, Metronal, and Roscal, is a typical antipsychotic of the phenothiazine group described as a neuroleptic and antihistamine.[1] It was first introduced in Germany in 1969. It is used as a neuroleptic, anxiolytic, and antihistamine in doses between 12.5 and 75 mg a day.
Synthesis
Sodamide alkylation of phenothiazine (1) with 1-bromo-3-chloro-2-methylpropane (2) gives 10-(3-Chloro-2-methylpropyl)phenothiazine (3).[2][3] Completion of the sidechain by alkylation with 1-[2-(2-hydroxyethoxy)ethyl]piperazine (4) and displacement of the halogen completes the synthesis of dixyrazine (5).
References
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- ↑ Script error: No such module "citation/CS1".
- ↑ Thieme
- ↑ Henri Morren, <templatestyles src="Citation/styles.css"/>Template:Citation/make linkScript error: No such module "Check for unknown parameters". (1961).
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