Diphenylpyraline

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Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.[1][2][3] It is marketed in Europe for the treatment of allergies.[1][2][4] DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents.[5] It has been shown to be useful in the treatment of Parkinsonism.[6]

Synthesis

File:Diphenylpyraline-synthesis.svg
Diphenylpyraline synthesis via coupling of 4-hydroxy-1-methylpiperidine with benzhydrylbromide[7][8]

References

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  8. <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Schuler WA, "Verfahren zur Herstellung von basischen Benzhydryläthern [Process for the production of basic benzhydrylethers]", issued Script error: No such module "auto date formatter"., assigned to Chemische Fabrik Promonta LLC. Script error: No such module "Check for unknown parameters".

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