Dimetofrine
Template:Short description Template:Drugbox
Dimetofrine (INN), also known as dimethophrine or dimetophrine and sold under the brand names Dovida, Pressamina, and Superten, is a medication described as a sympathomimetic, vasoconstrictor, and cardiac stimulant.[1][2][3] It is said to be similarly or less effective than midodrine in the treatment of orthostatic hypotension and shows substantially lower potency.[4][5]
The drug is a selective α1-adrenergic receptor agonist[6] but is also said to have β-adrenergic receptor agonist activity.[5] It is a substituted phenethylamine and is also known as 3,5-dimethoxy-4,β-dihydroxy-N-methylphenethylamine.[1] Its chemical structure is similar to that of desglymidodrine (3,6-dimethoxy-β-hydroxyphenethylamine), the active metabolite of midodrine.[4]
Dimetofrine remained marketed only in Italy in 2000.[2]
References
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