Di Stefano

Di Stefano is a patronymic Italian surname meaning "(the son) of Stephen". Notable people with the surname include:

• Alfredo Di Stéfano (1926–2014), Argentinian-Spanish footballer
• Andrea Di Stefano (born 1972), Italian actor
• Francesco di Stefano (c. 1422–1457), Italian painter
• Giordana Di Stefano (1995–2015), Italian femicide victim
• Giovanni di Stefano (disambiguation), several people
• Giuseppe Di Stefano (1921–2008), Italian tenor
• Manlio Di Stefano (born 1981), Italian politician
• Sergio Di Stefano (1939–2010), Italian voice actor
• Vincenzo di Stefano da Verona, Italian painter
• Phil DiStefano (born 1946), 11th Chancellor of University of Colorado Boulder