Desmethoxyyangonin
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| Appearance | white to faint yellow powder |
| Density | 1.18 g/mL |
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Desmethoxyyangonin or 5,6-dehydrokavain is one of the six main kavalactones found in the Piper methysticum (kava) plant. It is a reversible inhibitor of monoamine oxidase B (MAO-B), likely contributing to increased dopamine levels in the brain’s nucleus accumbens and supporting kava’s attention-enhancing effects. Unlike other kavalactones, it does not modulate GABAA receptors. It also strongly induces the liver enzyme CYP3A23. It is an active compound in Alpinia pricei with anti-inflammatory and liver-protective effects that improve survival in mice with endotoxin-induced hepatitis.
Pharmacology
Desmethoxyyangonin is a reversible inhibitor of monoamine oxidase B (MAO-B).[1] Kava is able to increase dopamine levels in the nucleus accumbens[2] and desmethoxyyangonin likely contributes to this effect. This, along with several other catecholamines, may be responsible for the purported attention-promoting effects of kava.
Unlike the other major kavalactones, desmethoxyyangonin does not appear to act as a GABAA receptor positive allosteric modulator.[3]
Desmethoxyyangonin has marked activity on the induction of CYP3A23.[4]
It is an active compound in the Formosan plant Alpinia pricei and exhibits potent anti-inflammatory and hepatoprotective effects by inhibiting immune cell activation and key inflammatory signaling pathways, significantly improving survival and metabolic balance in mice with endotoxin-induced fulminant hepatitis.[5]
See also
References
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- ↑ Chou T-W, Feng J-H, Huang C-C, Cheng Y-W, Chien S-C, Wang S-Y, et al. (2013) A Plant Kavalactone Desmethoxyyangonin Prevents Inflammation and Fulminant Hepatitis in Mice. PLoS ONE 8(10): e77626. doi:10.1371/journal.pone.0077626
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