Debrisoquine
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| MeSH | Debrisoquine |
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| Template:Longitem | C10H13N3 |
| Molar mass | 175.23032 |
| Template:Longitem | C02CC04 (WHO) |
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Debrisoquine is a derivative of guanidine. It is an antihypertensive drug similar to guanethidine. Debrisoquine is frequently used for phenotyping the CYP2D6 enzyme, a drug-metabolizing enzyme.[2]
Debrisoquine has been identified as a inhibitor of TMPRSS2 protease, which is involved in the viral entry process of SARS-CoV-2. In a laboratory study, it showed antiviral activity by blocking the ability of the virus to enter human lung cells.[3]
The guanidine part of the molecule also appears in guanoxan and guanadrel.Script error: No such module "Unsubst". The 7-bromo analog of debrisoquine is called guanisoquin.Script error: No such module "Unsubst".
See also
References
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- ↑ Debrisoquine – Compound Summary, PubChem.
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