dTDP-4-dehydrorhamnose reductase

Template:Infobox enzyme In enzymology, a dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) is an enzyme that catalyzes the chemical reaction

dTDP-6-deoxy-L-mannose + NADP⁺ $\rightleftharpoons$ dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H⁺

Thus, the two substrates of this enzyme are dTDP-6-deoxy-L-mannose and NADP⁺, whereas its 3 products are dTDP-4-dehydro-6-deoxy-L-mannose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is dTDP-6-deoxy-L-mannose:NADP⁺ 4-oxidoreductase. Other names in common use include dTDP-4-keto-L-rhamnose reductase, reductase, thymidine diphospho-4-ketorhamnose, dTDP-4-ketorhamnose reductase, TDP-4-keto-rhamnose reductase, and thymidine diphospho-4-ketorhamnose reductase. This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1KBZ, 1KC1, 1KC3, 1N2S, and 2GGS.

References

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