DLK1
Template:Cs1 config Template:Short description Template:Infobox gene Protein delta homolog 1, delta like non-canonical Notch ligand 1, fetal antigen 1[1] or preadipocyte factor 1[2] is a protein that in humans is encoded by the DLK1 gene.[3][4][5]
It is expressed as a transmembrane protein, but a soluble form cleaved off by ADAM17 is active in inhibiting adipogenesis,[6] the differentiation of pre-adipocytes into adipocytes.[7]
It is a member of the EGF-like family of homeotic proteins.[8]
Part of the Dlk1-DIO3 imprinting control region, this gene is one involved in the epigenetic process that causes a subset of genes to be regulated based on their parental origin.[9]
Such imprinted genes are required for the formation of the placenta as well as the development of cellular lineages such as those derived from the mesoderm and ectoderm.[10]
References
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- ↑ EntrezGene 8788
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- ↑ Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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Further reading
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