DENND1B
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Template:Short description Script error: No such module "Unsubst". Template:Infobox gene DENN domain-containing protein 1B is a protein encoded by DENND1B human gene, located on chromosome 1.
Structure
The protein has tripartite DENN domain at N-terminal.
Functions
The protein is a guanine nucleotide exchange factor for RAB35.[1]
Clinical significance
The gene is hypothesized by Danish scientists Klaus Bønnelykke and Hans Bisgaard to be related to asthma.[2] The gene may affect susceptibility to chronic cavitary pulmonary aspergillosis.[3] Variants of this gene are also associated with obesity in both humans and dogs.[4]
References
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