Community Programs for Clinical Research on AIDS
Template:Short description The Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) was a program sponsored by National Institutes of Health (NIH) in the United States.[1][2] Started in 1989, CPCRA was instrumental in some research databases being established. Research from the programs assisted the evaluation of therapies for treating HIV in diverse populations.Script error: No such module "Unsubst".
History
CPCRA was established in 1989[3] and included 15 research units. A Statistical Center at the University of Minnesota was funded from 1990 to 1997.[4][5]
CPCRA was one of four networks that NIH was using to conduct clinical trials that were looking to understand possible therapies for people with HIV infection.[6] Th CPCRA network was community-based with access to diverse populations across the spectrum of HIV diseases..."[7] The overall objective of the CPCRA is to design studies of sufficient size and duration of follow up to evaluate the long-term benefits and unintended consequences of various treatment strategies using available agents to assess long-term immunologic, virology and clinical outcomes. CPCRA trials are designed with nested sub-studies aimed at understanding the pathogenesis of HIV infection and the public health implications of its treatment.[8]
By 2001, CPCRA had 4,244 people participating in their studies, with trials underway in 17 cities.[9]
The International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) bio-repository system has its roots in the CPCRA.[10]
Research
An antiretroviral medication self-reporting questionnaire was developed by the program.[11] The program organised the 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trial: a large, long-term, randomised, prospective comparison of three different antiretroviral strategies in highly active antiretroviral therapy-naïve, HIV-1-infected persons.[12]
References
<templatestyles src="Reflist/styles.css" />
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
Script error: No such module "Check for unknown parameters".