Cmin
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CminScript error: No such module "Check for unknown parameters". is a term used in pharmacokinetics for the minimum blood plasma concentration reached by a drug during a dosing interval, which is the time interval between administration of two doses. This definition is slightly different from CtroughScript error: No such module "Check for unknown parameters"., the concentration immediately prior to administration of the next dose.[1] CminScript error: No such module "Check for unknown parameters". is the opposite of CmaxScript error: No such module "Check for unknown parameters"., the maximum concentration that the drug reaches. CminScript error: No such module "Check for unknown parameters". must be above certain thresholds, such as the minimum inhibitory concentration (MIC), to achieve a therapeutic effect.[2]
In most cases CminScript error: No such module "Check for unknown parameters". is directly measurable. At steady state the minimum plasma concentration can also be calculated using the following equation:[3]
- Template:Mvar = Salt factor
- Template:Mvar = Bioavailability
- Template:Mvar = Dose
- keScript error: No such module "Check for unknown parameters". = Elimination rate constant
- kaScript error: No such module "Check for unknown parameters". = Absorption rate constant
- VdScript error: No such module "Check for unknown parameters". = Volume of distribution
- Template:Mvar = Dosing interval
CminScript error: No such module "Check for unknown parameters". is also an important parameter in bioavailability and bioequivalence studies, it is part of the pharmacokinetic information recommended for submission of investigational new drug applications.[4]
References
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- ↑ Script error: No such module "citation/CS1". (pages 31–34 in 2003 edition)
- ↑ Script error: No such module "Citation/CS1".
- ↑ http://www.pharmpress.com/files/docs/clinical_pharmacokinetics_samplechapter.pdf Script error: No such module "webarchive". Template:Bare URL PDF
- ↑ fda.gov Template:Bare URL PDF
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