Clinofibrate

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Clinofibrate (INN; trade name Lipoclin) is pharmaceutical drug of the fibrate class that is used for managing hyperlipidemia and associated conditions.[1] It is sold and marketed in Japan.[2]

Chemically, it is a derivative of bisphenol Z.[3]

Synthesis

The condensation between cyclohexanone (1) and phenol (2) gives bisphenol Z (3).[4] This is treated with chloroform and methyl ethyl ketone (MEK) in the presence of base. The resulting Bargellini reaction gives clinofibrate (4).[5]

File:Clinofibrate synthesis.svg
Synthesis of clinofibrate

References

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