Ciclazindol
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Ciclazindol (WY-23409) is an antidepressant and anorectic[1] drug of the tetracyclicScript error: No such module "Unsubst". chemical class that was developed in the mid to late 1970s, but was never marketed.[2][3] It acts as a norepinephrine reuptake inhibitor, and to a lesser extent as a dopamine reuptake inhibitor.[2][4] Ciclazindol has no effects on the SERT, 5-HT receptors, mACh receptors, or α-adrenergic receptors, and has only weak affinity for the H1 receptor.[4][5][6] As suggested by its local anesthetic properties,[5] ciclazindol may also inhibit sodium channels. It is known to block potassium channels as well.[7][8]
The dosage in human volunteers is stated to be 25mg daily.[9] However, doses of up to 200mg have also been reported.[1] This is surprising since the dosage of mazindol is only 2-4mg per day.
Ciclazindol is reported to have an IC50 of 1.3nM for the dopamine transporter (cmp 23).[10]
See also
References
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