Chromosome 8

Template:Short description Template:Infobox chromosome Chromosome 8 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 8 spans about 146 million base pairs (the building material of DNA) and represents between 4.5 and 5.0% of the total DNA in cells.

About 8% of its genes are involved in brain development and function, and about 16% are involved in cancer. A unique feature of 8p is a region of about 15 megabases that appears to have a high mutation rate. This region shows a significant divergence between human and chimpanzee, suggesting that its high mutation rates have contributed to the evolution of the human brain.

Genes

Number of genes

The following are some of the gene count estimates of human chromosome 8. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.

Estimated by	Protein-coding genes	Non-coding RNA genes	Pseudogenes	Source	Release date
CCDS	646	—	—		2016-09-08
HGNC	656	242	539		2017-05-12
Ensembl	670	1,052	613		2017-03-29
UniProt	703	—	—		2018-02-28
NCBI	719	848	682		2017-05-19

Gene list

Template:Category see also/Category pair check The following is a partial list of genes on human chromosome 8. For complete list, see the link in the infobox on the right. Template:Columns-list

Diseases and disorders

The following diseases and disorders are some of those related to genes on chromosome 8: Template:Div col

• 8p23.1 duplication syndrome
• Bipolar disorder
• Burkitt lymphoma
• Charcot–Marie–Tooth disease
• COACH syndrome
• Cleft lip and cleft palate
• Cohen syndrome
• Congenital hypothyroidism
• Fahr's syndrome
• Hereditary multiple exostoses
• Lipoprotein lipase deficiency, familial
• Monosomy 8p
• Myelodysplastic syndrome
• Pfeiffer syndrome
• Primary microcephaly
• Rothmund–Thomson syndrome
• Schizophrenia, associated with 8p21-22 locus
• Waardenburg syndrome
• Werner syndrome
• Pingelapese blindness
• Langer–Giedion syndrome
• Roberts syndrome
• Hepatocellular carcinoma
• Sanfilippo syndromeTemplate:Div col end

Cytogenetic band

G-bands of human chromosome 8 in resolution 850 bphs

Chr.	Arm	Band	ISCN start	ISCN stop	Basepair start	Basepair stop	Stain	Density
8	p	23.3	0	115	Template:Val	Template:Val	gneg
8	p	23.2	115	331	Template:Val	Template:Val	gpos	75
8	p	23.1	331	690	Template:Val	Template:Val	gneg
8	p	22	690	992	Template:Val	Template:Val	gpos	100
8	p	21.3	992	1179	Template:Val	Template:Val	gneg
8	p	21.2	1179	1380	Template:Val	Template:Val	gpos	50
8	p	21.1	1380	1639	Template:Val	Template:Val	gneg
8	p	12	1639	1897	Template:Val	Template:Val	gpos	75
8	p	11.23	1897	2041	Template:Val	Template:Val	gneg
8	p	11.22	2041	2156	Template:Val	Template:Val	gpos	25
8	p	11.21	2156	2343	Template:Val	Template:Val	gneg
8	p	11.1	2343	2472	Template:Val	Template:Val	acen
8	q	11.1	2472	2645	Template:Val	Template:Val	acen
8	q	11.21	2645	2817	Template:Val	Template:Val	gneg
8	q	11.22	2817	3033	Template:Val	Template:Val	gpos	75
8	q	11.23	3033	3277	Template:Val	Template:Val	gneg
8	q	12.1	3277	3493	Template:Val	Template:Val	gpos	50
8	q	12.2	3493	3622	Template:Val	Template:Val	gneg
8	q	12.3	3622	3809	Template:Val	Template:Val	gpos	50
8	q	13.1	3809	3938	Template:Val	Template:Val	gneg
8	q	13.2	3938	4096	Template:Val	Template:Val	gpos	50
8	q	13.3	4096	4312	Template:Val	Template:Val	gneg
8	q	21.11	4312	4545	Template:Val	Template:Val	gpos	100
8	q	21.12	4545	4628	Template:Val	Template:Val	gneg
8	q	21.13	4628	4858	Template:Val	Template:Val	gpos	75
8	q	21.2	4858	4959	Template:Val	Template:Val	gneg
8	q	21.3	4959	5289	Template:Val	Template:Val	gpos	100
8	q	22.1	5289	5577	Template:Val	Template:Val	gneg
8	q	22.2	5577	5692	Template:Val	Template:Val	gpos	25
8	q	22.3	5692	5922	Template:Val	Template:Val	gneg
8	q	23.1	5922	6152	Template:Val	Template:Val	gpos	75
8	q	23.2	6152	6267	Template:Val	Template:Val	gneg
8	q	23.3	6267	6611	Template:Val	Template:Val	gpos	100
8	q	24.11	6611	6726	Template:Val	Template:Val	gneg
8	q	24.12	6726	6942	Template:Val	Template:Val	gpos	50
8	q	24.13	6942	7244	Template:Val	Template:Val	gneg
8	q	24.21	7244	7431	Template:Val	Template:Val	gpos	50
8	q	24.22	7431	7661	Template:Val	Template:Val	gneg
8	q	24.23	7661	7804	Template:Val	Template:Val	gpos	75
8	q	24.3	7804	8250	Template:Val	Template:Val	gneg