Chromosome 3
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Template:Short description Template:Infobox chromosome Chromosome 3 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 3 spans more than 201 million base pairs (the building material of DNA) and represents about 6.5 percent of the total DNA in cells.
Genes
Number of genes
The following are some of the gene count estimates of human chromosome 3. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[1]
| Estimated by | Protein-coding genes | Non-coding RNA genes | Pseudogenes | Source | Release date |
|---|---|---|---|---|---|
| CCDS | 1,024 | — | — | [2] | 2016-09-08 |
| HGNC | 1,036 | 483 | 761 | [3] | 2017-05-12 |
| Ensembl | 1,073 | 1,158 | 761 | [4] | 2017-03-29 |
| UniProt | 1,081 | — | — | [5] | 2018-02-28 |
| NCBI | 1,085 | 1,108 | 902 | [6][7][8] | 2017-05-19 |
List of genes
Script error: No such module "Category see also".Template:Category see also/Category pair check The following is a partial list of genes on human chromosome 3. For complete list, see the link in the infobox on the right.
p-arm
Partial list of the genes located on p-arm (short arm) of human chromosome 3: Script error: No such module "Template wrapper".Script error: No such module "Check for unknown parameters".
q-arm
Partial list of the genes located on q-arm (long arm) of human chromosome 3: Script error: No such module "Template wrapper".Script error: No such module "Check for unknown parameters".
Diseases and disorders
Template:Expand list The following diseases and disorders are some of those related to genes on chromosome 3:
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- 3-Methylcrotonyl-CoA carboxylase deficiency
- 3q29 microdeletion syndrome
- Acute myeloid leukemia (AML)
- Alkaptonuria
- Arrhythmogenic right ventricular dysplasia
- Atransferrinemia
- Autism
- Autosomal dominant optic atrophy
- ADOA plus syndrome
- Biotinidase deficiency
- Blepharophimosis, epicanthus inversus and ptosis type 1
- Breast/colon/lung/pancreatic cancer
- Brugada syndrome
- Castillo fever
- Carnitine-acylcarnitine translocase deficiency
- Cataracts
- Cerebral cavernous malformation
- Charcot–Marie–Tooth disease, type 2
- Charcot–Marie–Tooth disease
- Chromosome 3q duplication syndrome
- Coproporphyria
- A location on human chromosome 3 is associated with respiratory failure and possibly with increased severity in COVID-19[10][11]
- Dandy–Walker syndrome
- Deafness
- Diabetes
- Dystrophic epidermolysis bullosa
- Endplate acetylcholinesterase deficiency
- Essential tremors
- Ectrodactyly, Case 4
- Glaucoma, primary open angle
- Glycogen storage disease
- Hailey–Hailey disease
- Harderoporphyrinuria
- Heart block, progressive/nonprogressive
- Hereditary coproporphyria
- Hereditary nonpolyposis colorectal cancer
- HIV infection, susceptibility/resistance to
- Hypobetalipoproteinemia, familial
- Hypothermia
- Leukoencephalopathy with vanishing white matter
- Long QT syndrome
- Lymphomas
- Malignant hyperthermia susceptibility
- Metaphyseal chondrodysplasia, Murk Jansen type
- Microcoria
- Möbius syndrome
- Moyamoya disease
- Mucopolysaccharidosis
- Muir–Torre family cancer syndrome
- Myotonic dystrophy
- Neuropathy, hereditary motor and sensory, Okinawa type
- Night blindness
- Nonsyndromic deafness
- Ovarian cancer
- Porphyria
- Propionic acidemia
- Protein S deficiency
- Pseudocholinesterase deficiency
- Pseudo-Zellweger syndrome
- Retinitis pigmentosa
- Romano–Ward syndrome
- Seckel syndrome
- Sensenbrenner syndrome
- Septo-optic dysplasia
- Short stature
- Spinocerebellar ataxia
- Sucrose intolerance
- T-cell leukemia translocation altered gene
- Usher syndrome
- von Hippel–Lindau syndrome
- Waardenburg syndrome
- Xeroderma pigmentosum, complementation group c
Cytogenetic band
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| Chr. | Arm[13] | Band[14] | ISCN start[15] |
ISCN stop[15] |
Basepair start |
Basepair stop |
Stain[16] | Density |
|---|---|---|---|---|---|---|---|---|
| 3 | p | 26.3 | 0 | 175 | Script error: No such module "val". | Script error: No such module "val". | gpos | 50 |
| 3 | p | 26.2 | 175 | 263 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 26.1 | 263 | 408 | Script error: No such module "val". | Script error: No such module "val". | gpos | 50 |
| 3 | p | 25.3 | 408 | 642 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 25.2 | 642 | 759 | Script error: No such module "val". | Script error: No such module "val". | gpos | 25 |
| 3 | p | 25.1 | 759 | 963 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 24.3 | 963 | 1269 | Script error: No such module "val". | Script error: No such module "val". | gpos | 100 |
| 3 | p | 24.2 | 1269 | 1357 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 24.1 | 1357 | 1561 | Script error: No such module "val". | Script error: No such module "val". | gpos | 75 |
| 3 | p | 23 | 1561 | 1751 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 22.3 | 1751 | 1926 | Script error: No such module "val". | Script error: No such module "val". | gpos | 50 |
| 3 | p | 22.2 | 1926 | 2013 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 22.1 | 2013 | 2188 | Script error: No such module "val". | Script error: No such module "val". | gpos | 75 |
| 3 | p | 21.33 | 2188 | 2451 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 21.32 | 2451 | 2626 | Script error: No such module "val". | Script error: No such module "val". | gpos | 50 |
| 3 | p | 21.31 | 2626 | 3239 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 21.2 | 3239 | 3385 | Script error: No such module "val". | Script error: No such module "val". | gpos | 25 |
| 3 | p | 21.1 | 3385 | 3676 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 14.3 | 3676 | 3910 | Script error: No such module "val". | Script error: No such module "val". | gpos | 50 |
| 3 | p | 14.2 | 3910 | 4143 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 14.1 | 4143 | 4362 | Script error: No such module "val". | Script error: No such module "val". | gpos | 50 |
| 3 | p | 13 | 4362 | 4566 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 12.3 | 4566 | 4814 | Script error: No such module "val". | Script error: No such module "val". | gpos | 75 |
| 3 | p | 12.2 | 4814 | 4946 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 12.1 | 4946 | 5077 | Script error: No such module "val". | Script error: No such module "val". | gpos | 75 |
| 3 | p | 11.2 | 5077 | 5135 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | p | 11.1 | 5135 | 5266 | Script error: No such module "val". | Script error: No such module "val". | acen | |
| 3 | q | 11.1 | 5266 | 5427 | Script error: No such module "val". | Script error: No such module "val". | acen | |
| 3 | q | 11.2 | 5427 | 5602 | Script error: No such module "val". | Script error: No such module "val". | gvar | |
| 3 | q | 12.1 | 5602 | 5762 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 12.2 | 5762 | 5850 | Script error: No such module "val". | Script error: No such module "val". | gpos | 25 |
| 3 | q | 12.3 | 5850 | 5996 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 13.11 | 5996 | 6229 | Script error: No such module "val". | Script error: No such module "val". | gpos | 75 |
| 3 | q | 13.12 | 6229 | 6361 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 13.13 | 6361 | 6594 | Script error: No such module "val". | Script error: No such module "val". | gpos | 50 |
| 3 | q | 13.2 | 6594 | 6682 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 13.31 | 6682 | 6871 | Script error: No such module "val". | Script error: No such module "val". | gpos | 75 |
| 3 | q | 13.32 | 6871 | 6973 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 13.33 | 6973 | 7148 | Script error: No such module "val". | Script error: No such module "val". | gpos | 75 |
| 3 | q | 21.1 | 7148 | 7294 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 21.2 | 7294 | 7440 | Script error: No such module "val". | Script error: No such module "val". | gpos | 25 |
| 3 | q | 21.3 | 7440 | 7674 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 22.1 | 7674 | 7936 | Script error: No such module "val". | Script error: No such module "val". | gpos | 25 |
| 3 | q | 22.2 | 7936 | 8053 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 22.3 | 8053 | 8228 | Script error: No such module "val". | Script error: No such module "val". | gpos | 25 |
| 3 | q | 23 | 8228 | 8461 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 24 | 8461 | 8811 | Script error: No such module "val". | Script error: No such module "val". | gpos | 100 |
| 3 | q | 25.1 | 8811 | 9001 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 25.2 | 9001 | 9162 | Script error: No such module "val". | Script error: No such module "val". | gpos | 50 |
| 3 | q | 25.31 | 9162 | 9264 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 25.32 | 9264 | 9366 | Script error: No such module "val". | Script error: No such module "val". | gpos | 50 |
| 3 | q | 25.33 | 9366 | 9453 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 26.1 | 9453 | 9803 | Script error: No such module "val". | Script error: No such module "val". | gpos | 100 |
| 3 | q | 26.2 | 9803 | 9949 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 26.31 | 9949 | 10183 | Script error: No such module "val". | Script error: No such module "val". | gpos | 75 |
| 3 | q | 26.32 | 10183 | 10329 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 26.33 | 10329 | 10489 | Script error: No such module "val". | Script error: No such module "val". | gpos | 75 |
| 3 | q | 27.1 | 10489 | 10620 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 27.2 | 10620 | 10737 | Script error: No such module "val". | Script error: No such module "val". | gpos | 25 |
| 3 | q | 27.3 | 10737 | 10883 | Script error: No such module "val". | Script error: No such module "val". | gneg | |
| 3 | q | 28 | 10883 | 11175 | Script error: No such module "val". | Script error: No such module "val". | gpos | 75 |
| 3 | q | 29 | 11175 | 11700 | Script error: No such module "val". | Script error: No such module "val". | gneg |
See also
References
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- ↑ Script error: No such module "Citation/CS1".
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- ↑ CRBN cereblon [Homo sapiens (human)] - Gene - NCBI
- ↑ Script error: No such module "citation/CS1".
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- ↑ "p": Short arm; "q": Long arm.
- ↑ For cytogenetic banding nomenclature, see article locus.
- ↑ a b These values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit.
- ↑ gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk.
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External links
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