Chromosome 11

Template:Short description Template:Infobox chromosome Chromosome 11 is one of the 23 pairs of chromosomes in humans. Humans normally have two copies of this chromosome. Chromosome 11 spans about 135 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells. The shorter arm (p arm) is termed 11p while the longer arm (q arm) is 11q. At about 21.5 genes per megabase, chromosome 11 is one of the most gene-rich, and disease-rich, chromosomes in the human genome.

More than 40% of the 856 olfactory receptor genes in the human genome are located in 28 single-gene and multi-gene clusters along the chromosome.

Gene

Number of genes

The following are some of the gene count estimates of human chromosome 11. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.

Estimated by	Protein-coding genes	Non-coding RNA genes	Pseudogenes	Source	Release date
CCDS	1,224	—	—		2016-09-08
HGNC	1,262	271	666		2017-05-12
Ensembl	1,301	1,060	811		2017-03-29
UniProt	1,327	—	—		2018-02-28
NCBI	1,314	860	839		2017-05-19

Gene list

Template:Category see also/Category pair check The following is a partial list of genes on human chromosome 11. For complete list, see the links in the infobox on the right.

Diseases and disorders

The following diseases and disorders are some of those related to genes on chromosome 11:

• autism (NRXN2)
• acute intermittent porphyria
• albinism
• ataxia–telangiectasia
• Beckwith–Wiedemann syndrome
• Best's disease
• beta-ketothiolase deficiency
• beta thalassemia
• bipolar disorder
• bladder cancer
• breast cancer
• carnitine palmitoyltransferase I deficiency
• Charcot–Marie–Tooth disease
• Cystic fibrosis
• Depression
• Denys–Drash syndrome
• familial Mediterranean fever
• Hereditary angioedema OMIM: 106100
• Jacobsen syndrome
• Jervell and Lange-Nielsen syndrome
• Mantle cell lymphoma (t11;14)
• Meckel syndrome
• methemoglobinemia, beta-globin type
• Mixed lineage leukemia
• multiple endocrine neoplasia type 1
• Hereditary multiple exostoses
• Nestor-Guillermo progeria syndrome
• Niemann–Pick disease
• nonsyndromic deafness
• porphyria
• Potocki–Shaffer syndrome
• Romano–Ward syndrome
• Sickle cell anemia
• Smith–Lemli–Opitz syndrome
• tetrahydrobiopterin deficiency
• Usher syndrome
• WAGR syndrome
• Wiedemann–Steiner syndrome
• Wilms' tumor
• Mosaic variegated aneuploidy syndrome

Cytogenetic band

G-bands of human chromosome 11 in resolution 850 bphs

Chr.	Arm	Band	ISCN start	ISCN stop	Basepair start	Basepair stop	Stain	Density
11	p	15.5	0	230			gneg
11	p	15.4	230	461			gpos	50
11	p	15.3	461	745			gneg
11	p	15.2	745	935			gpos	50
11	p	15.1	935	1246			gneg
11	p	14.3	1246	1490			gpos	100
11	p	14.2	1490	1545			gneg
11	p	14.1	1545	1775			gpos	75
11	p	13	1775	2114			gneg
11	p	12	2114	2357			gpos	100
11	p	11.2	2357	2655			gneg
11	p	11.12	2655	2872			gpos	75
11	p	11.11	2872	3035			acen
11	q	11	3035	3197			acen
11	q	12.1	3197	3414			gpos	75
11	q	12.2	3414	3550			gneg
11	q	12.3	3550	3685			gpos	25
11	q	13.1	3685	4037			gneg
11	q	13.2	4037	4186			gpos	25
11	q	13.3	4186	4512			gneg
11	q	13.4	4512	4688			gpos	50
11	q	13.5	4688	4877			gneg
11	q	14.1	4877	5148			gpos	100
11	q	14.2	5148	5257			gneg
11	q	14.3	5257	5474			gpos	100
11	q	21	5474	5690			gneg
11	q	22.1	5690	5934			gpos	100
11	q	22.2	5934	6070			gneg
11	q	22.3	6070	6300			gpos	100
11	q	23.1	6300	6503			gneg
11	q	23.2	6503	6693			gpos	50
11	q	23.3	6693	7167			gneg
11	q	24.1	7167	7316			gpos	50
11	q	24.2	7316	7533			gneg
11	q	24.3	7533	7695			gpos	50
11	q	25	7695	7980			gneg