Calyculin
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Template:Chembox Calyculins are natural products originally isolated from the marine sponge Discodermia calyx.[1] Calyculins have proven to be strong serine/threonine protein phosphatase inhibitors and based on this property, calyculins might be potential tumor-promoting agents.
A laboratory synthesis of calyculin A has been reported.[2]
Biosynthesis
Calyculin A is biosynthesized as a pyrophosphate containing phosphocalyculin A protoxins by a hybrid PKS-NRPS pathway within the sponge bacterial symbiont, "Candidatus Entotheonella" sp.[3]
References
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