Calcitonin receptor

Template:Cs1 config Template:Short description Template:Infobox gene The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism.

CT works by activating the G-proteins G_s and G_q often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain. It may also affect the ovaries in women and the testes in men.

The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY₁ (CT + RAMP1), AMY₂ (CT + RAMP2), and AMY₃ (CT+ RAMP3).

Preclinical studies have suggested that dual amylin and calcitonin receptor agonists may be more effective than amylin receptor agonists for obesity and type II diabetes.

Interactions

File:Human calcitonin recptor-Gs complex PDB 7TYO.png

Structure of human calcitonin recptor-G_s complex. The transmembrane calcitonin receptor (blue) is bound to human calcitonin (red) and the G_s complex (yellow). Template:PDB

Calcitonin receptor has been shown to interact with Apolipoprotein B and LRP1.

External links

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