CXXC5
Template:Short description Template:Cs1 config Template:Infobox gene CXXC-type zinc finger protein 5 is a protein that is encoded by the CXXC5 gene in humans.[1][2][3][4]
As indicated by its name, the CXXC5 plays a role as a transcription factor in the nucleus of cells, and involved in myelopoiesis, endothelial differentiation, vessel formation, and oligodendrocyte differentiation.[5][6][3]
The CXXC5 is also characterized as a negative feedback regulator of the Wnt/β-catenin signaling pathway functioning by direct interaction with the Dishevelled (Dvl) protein in the cytosol.[2][5][7][8][9] The cytosolic overexpression of CXXC5 was induced by several pathophysiological conditions, such as osteoporosis, alopecia, senescence of growth plate, cutaneous wound, and restoration of the suppressed Wnt/β-catenin signaling by blockade of its Dvl binding function improved the pathological features as observed in Cxxc5-/- mice.[5][8][9][10] These results indicate that the Dvl binding with cytosolic CXXC5 could be a target for the development of agents for treating alopecia, acute wound, and short stature in childhood and adolescence, which exhibit suppressed Wnt/β-catenin signaling by cytosolic CXXC5 overexpression of the responsible tissue cells.[7][9][11] The CXXC5-Dvl protein-protein interaction (PPI) as a target for development of agents in hair loss or acute wound was also confirmed by construction and testing the function of PTD-DBM, a peptide inhibiting the CXXC5-Dvl PPIl.[7][9]
The improvement of abnormalities by the CXXC5-Dvl PPI inhibitor is attributed to restoration of damaged tissues by activating the stem cells through restorative activation of the suppressed Wnt/β-catenin signaling and its target genes involving regeneration.
References
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Further reading
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External links
- Template:UCSC gene info
- GRCh38: Ensembl release 89: ENSG00000171604 - Ensembl, May 2017
- GRCm38: Ensemble release 89: ENSMUSG00000046668 - Ensembl, May 2017
- "Human PubMed Reference" National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Human PubMed Reference" National Center for Biotechnology Information, U.S. National Library of Medicine.