CSNK1E
Template:Short description Template:Infobox gene Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.[1][2]
Function
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate proteins of the Period family of circadian rhythm proteins. A homolog of this mammalian protein can be found in Drosophila melanogaster. Known as doubletime, this protein also plays a role in the phosphorylation of proteins involved in circadian rhythms. Two transcript variants encoding the same protein have been found for this gene.[3]
Interactions
CSNK1E has been shown to interact with PER1[4] and AXIN1.[5]
Inhibitors
- Selective
- Non-selective
- PF-670462 (also inhibits CK1-δ)
See also
References
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External links
- Template:UCSC gene info
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Casein kinase I isoform epsilon (CSNK1E)