CPSF2

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Template:Cs1 config Template:Short description

File:CPSF2 highlighted within CPSF complex.png
PDB-6V4X. CPSF2 protein highlighted within the CPSF complex. CPSF2 is rainbow colored. Other subunits of the complex are represented by solid colors.

Template:Infobox gene Cleavage and polyadenylation specificity factor subunit 2 is a protein that in humans is encoded by the CPSF2 gene.[1][2][3] This protein is a subunit of the cleavage and polyadenylation specificity factor (CPSF) complex which plays a key role in pre-mRNA 3' end processing and polyadenylation.[4] The CPSF2 protein connects the two subunits of the complex, mCF and mPSF.[4] Its structure contributes both to the stability of the subunits interaction and to the flexibility of the complex necessary for function.[5] This protein has been identified as an essential subunit of the complex as certain mutations in the region inhibit CPSF complex formation.[5]

References

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  1. ↑ Script error: No such module "Citation/CS1".
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  4. ↑ a b Script error: No such module "citation/CS1".
  5. ↑ a b Script error: No such module "Citation/CS1".

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External links

Further reading

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  • Script error: No such module "Citation/CS1".
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