COG4
Template:Short description Template:Infobox gene Conserved oligomeric Golgi complex subunit 4 is a protein that in humans is encoded by the COG4 gene.[1][2]
Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG4 (Ungar et al., 2002).[supplied by OMIM][2]
Interactions
COG4 has been shown to interact with COG7,[3] COG2,[3] COG1[3] and COG5.[3]
Clinical
Mutations in this gene have been associated with Saul-Wilson syndrome.[4]
References
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- ↑ Ferreira C (2020) Saul-Wilson syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. SourceGeneReviews. Seattle (WA): University of Washington, Seattle
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Further reading
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External links
- GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
- Template:UCSC gene info