CLDN18

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Template:Short description Template:Infobox gene Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.[1] It belongs to the group of claudins.

CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .[2] [supplied by OMIM][1]

Clinical significance

Isoform 2 (Claudin 18.2) is abundant in gastric tumors.[3]

Zolbetuximab targets Claudin 18.2 to help treat gastric cancers.[4]

References

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  3. ↑ Antibody Shines in Advanced Gastric Cancer - IMAB362 leads to longer remission, better survival. June 2016
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External links

Further reading

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