CLCNKB
Template:Short description Template:Infobox gene Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene.[1][2]
Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels.[3] Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome.[4] CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.[1]
See also
- Chloride channel
- BSND, barttin, accessory subunit beta for this channel
References
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Further reading
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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