CIZ1
Template:Short description Template:Infobox gene Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.[1][2]
Function
The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.[2]
Clinical significance
An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.[3]
Ciz1 mutant mice
Aged (18-mo-old) Ciz1-/- mice have increased neuronal DNA double-strand breaks that likely contributed to their loss of neurons and cognitive decline with age.[4] Embryonic fibroblasts from Ciz1-/- mice show abnormal sensitivity to γ-irradiation with persistent DNA breaks, aberrant cell cycle progression and increased apoptosis.[4]
Interactions
CIZ1 has been shown to interact with P21.[1]
References
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External links
Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.