CDC34

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Template:Short description Template:Cs1 config Template:Infobox gene CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1.[1][2][3] This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.[4]

CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell cycle.[5] Cdc34 in yeast targets numerous substrates - notably the cyclin-dependent kinase inhibitor Sic1[6] - for ubiquitin-mediated protein degradation.[7] CDC34 is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.[3]

Interactions

CDC34 has been shown to interact with CSNK2B,[8] BTRC[9][10] and CDK9.[11]

References

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External links

Further reading

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