CD98
Template:Cs1 config Template:Short description Script error: No such module "Infobox".Template:Template otherTemplate:Main otherScript error: No such module "Check for unknown parameters". Script error: No such module "Infobox".Template:Template otherTemplate:Main otherScript error: No such module "Check for unknown parameters". CD98 is a glycoprotein[1][2] that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids.[3] LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.[3]
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:
- 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene [4]
- CD98 light subunit protein encoded by the SLC7A5 gene[5]
See also
References
External links
Template:Clusters of differentiation Template:Membrane transport proteins