Integrin alpha V
Template:Short description Template:Cs1 config Template:Infobox gene Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.[1]
Function
ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.[2]
Alpha V class integrins
In mammals the integrins that include alpha-V are :
| Name | Synonyms | Distribution | Ligands |
|---|---|---|---|
| αVβ1 | neurological tumors | vitronectin; fibrinogen | |
| αVβ3 | vitronectin receptor[3] | activated endothelial cells, melanoma, glioblastoma | vitronectin,[3] fibronectin, fibrinogen, osteopontin, Cyr61, thyroxine[4][5] |
| αVβ5 | widespread, esp. fibroblasts, epithelial cells | vitronectin and adenovirus | |
| αVβ6 | proliferating epithelia, esp. lung and mammary gland | fibronectin; TGFβ1+3 | |
| αVβ8 | neural tissue; peripheral nerve | fibronectin; TGFβ1+3 |
Clinical significance
Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer,[6] and prostate cancer.[7]
As a drug target
The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.[8]
See also
References
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Further reading
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External links
- Template:MeshName
- ITGAV Info with links in the Cell Migration Gateway Template:Webarchive
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