Integrin beta 5

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Template:Cs1 config Template:Short description Template:Infobox gene Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.[1][2]

Interactions

Integrin, beta 5 has been shown to interact with PTK2,[3] Annexin A5[4] and PAK4.[5]

Functions

ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.[6]

Clinical significance

Research

Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.[7]

References

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Further reading

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External links

Template:Integrins


Template:Asbox

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