Butofilolol
Jump to navigation
Jump to search
Template:Short description Template:Cs1 config Template:Drugbox
Butofilolol (trade name Cafide) is a beta-blocker drug for the treatment of essential hypertension (high blood pressure).[1][2] It is not known to be marketed anywhere.
It is an example of a butyrophenone.
Synthesis
The Fries rearrangement of the ester formed by 4-fluorophenol (1)[3] and butryryl chloride (2) gives 5'-fluoro-2'-hydroxybutyrophenone (3). Treatment with epichlorohydrin in the presence of base leads to 1-[5-fluoro-2-(oxiranylmethoxy)phenyl]butan-1-one (4). Lastly, reaction with tert-butylamine gives butofilolol.[4][5]
References
<templatestyles src="Reflist/styles.css" />
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Demarne H, "ompositions for treatment of cardiovascular conditions associated with overproduction of catecholamines", issued Script error: No such module "auto date formatter"., assigned to C. M. IndustriesScript error: No such module "Check for unknown parameters".)
Script error: No such module "Check for unknown parameters".