Buthionine sulfoximine

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Buthionine sulfoximine
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MeSH Buthionine+sulfoximine
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Template:Longitem C8H18N2O3S
Molar mass 222.305 g/mol
Density 1.29 g/mL
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Buthionine sulfoximine (BSO) is a sulfoximine derivative which reduces levels of glutathione and is being investigated as an adjunct with chemotherapy in the treatment of cancer.[1] The compound inhibits gamma-glutamylcysteine synthetase, the enzyme required in the first step of glutathione synthesis. Buthionine sulfoximine may also be used to increase the sensitivity of parasites to oxidative antiparasitic drugs.[2]

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