Butacaine

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Butacaine
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Butacaine is a white crystalline ester used as a local anesthetic.[1] It was first marketed in 1920.[1]

Synthesis

The addition of metallic sodium is added to a mixture of allyl alcohol (1) and dibutylamine (2)[2] gives the conjugate addition product 3-dibutylamino-1-propanol (3). Esterification of this intermediate with para-nitrobenzoyl chloride (4) gives the ester 5. The reduction of the nitro group completes the synthesis of butacaine (6).[3][4][5][6][7][8]

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Synthesis of butacaine

See also

References

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  1. ↑ a b Script error: No such module "citation/CS1".
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  5. ↑ Oliver Kamm, Roger Adams, Volwiler Ernest H., U.S. patent 1358751 (1920 to Abbott Lab)
  6. ↑ Adams Roger, Ernest H Volwiler, U.S. patent 1676470 (1928 to Abbott Lab)
  7. ↑ Weston Arthur W, U.S. patent 2437984 (1948 to Abbott Lab)
  8. ↑ Anon., <templatestyles src="Citation/styles.css"/>Template:Citation/make link Script error: No such module "Check for unknown parameters". (1922-12-27 to Abbott Lab).

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