Beta1-adrenergic agonist
β1-Adrenergic receptor agonists, also known as beta-1 agonists, are a class of drugs that bind selectively to the β1-adrenergic receptor. As a result, they act more selectively upon the heart. β-Adrenoceptors typically bind to norepinephrine release by sympathetic adrenergic nerves and to circulating epinephrine. The effect of β-adrenoceptors is cardiac stimulation, such as increased heart rate, heart contractility, heart conduction velocity, and heart relaxation.[1]
Examples
Examples include:
- Denopamine (selective β1 agonist)[2][3]
- Dobutamine (β1>β2 agonist)
- Xamoterol (β1 partial agonist)
- Epinephrine (non-selective)
- Norepinephrine (non-selective)
- Isoprenaline (non-selective)
Norepinephrine reuptake inhibitors, like atomoxetine, methylphenidate, and cocaine, as well as norepinephrine releasing agents, like amphetamine, ephedrine, pseudoephedrine, and phenylpropanolamine, indirectly activate β1-adrenergic receptors (as well as other adrenergic receptors) by increasing norepinephrine and/or epinephrine levels.[4] As a result, they can be referred to as indirectly acting sympathomimetics.[4]
References
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- ↑ a b Biaggioni, I., & Robertson, D. (2018). Adrenoceptor Agonists & Sympathomimetic Drugs. Basic & Clinical Pharmacology, 14th Edition, 137–155. https://scholar.google.com/scholar?cluster=8160024720742860204
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Template:Receptor agonists and antagonists Template:Adrenergic receptor modulators